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This analysis revealed an interaction between the GSTT null allele and industrial plants within 500 m of the residences of childhood AL patients (interaction odds ratio, COR = 2.96, 95% CI: 1.09 8.01).
This would then enable a very easy computation of the interaction odds ratio.
Because relationships differed between intervention treatment arms based on tests of interaction, odds ratios (ORs) with 95% CIs are reported separately for DSE and ILI participants.
The interaction odds ratio (COR) for the gene-gene interaction between CYP1B1 1294G and SULT1A1 638allelele was 2.68 (95% CI: 1.16 6.26).
The interaction odds ratio between h1 and h2 is calculated using the method described by Thomas (2004), IOR m, n, where m and n denote dominant or recessive models imposed on h1 and h2, respectively, and 0 indicates the wildtype.
Call this Model 4. We add interaction odds ratios of 2 corresponding to the predictor pair (X 1,X2) to Model 4 and call it Model 5. We generate 1000 data points under each model and repeat 1000 times.
Similar(49)
Thus, to test for GxE interaction, one defines the interaction odds-ratio as OR I = OR01 × OR10/ OR11 and tests for H0: OR I = 1.
Finally, the models were examined for statistical interactions; odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
The strength of this association varied according to age (interaction): The odds ratio (OR) (95% CI) of anemia at PICU discharge was 4.85 (1.67–14.11) for 1 5-month-old infants anemic versus not anemic at PICU admission, and it was 73.1 5-month-old8.1 5-month-oldscents aneminfantsus not anemic at PICU admission.
There was also a small but significant interaction effect (odds ratio of 1.0119) between DSS and DMS.
In this interaction, an odds ratio less than 1.00 indicates that the positive relationship between hostile-ineffective parenting and hyperactivity-inattention was weaker for boys.
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