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Moreover, we obtained similar qualitative interaction link values (a difference of just 1.9%) in the comparison between control- periods (Supplementary Tables S3A and S4).
We considered our network as undirected, treating every link as an interaction link, to accommodate the input requirements to NetworkAnalyzer.
An interaction link was included, if a direct mechanism exists, but the link is neither known to be a stimulation, nor an inhibition.
For example, text terms such as 'interacts with', 'binds to' or 'forms a complex with' usually led to inclusion of an interaction link.
Ideally, the weight of a protein-protein interaction link should correspond to the affinity (strength) of the physical interaction between the two proteins.
In the context of the non-directional PPI network, the existence of an interaction link from one protein to another directly implies a link in the opposite direction, too.
Similar(52)
Morrison, A. J. et al. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.
Beekeeping disrupted the generalist wild pollinators and their interaction links, generating significant changes in their hierarchical structural organization.
Our results show that beekeeping reduces the diversity of wild pollinators and interaction links in the pollination networks.
Qa-1/NKG2A interaction linked the pathogen to host immunity, and accounted for impaired NK/T functions in the establishment of HCV persistence.
The reduction of both number of pollinator species and interaction links through apis-periods probably contributed substantially to the web simplification through shifts in network parameters.
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