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Exact(12)
This lack of a direct interaction is supported by previous tandem affinity purification experiments that used PRKCI as bait [32].
The functional importance of this interaction is supported by the observation that the ability of Themis2 to promote LPS-induced TNF production is significantly inhibited by mutation of Y660 (Fig 6c).
As expected, HapX itself does not repress sreA, even though this interaction is supported by source 3.
The involvement of W61 in the inter-domain interaction is supported by a network of inter- and intra-domain NOEs (Supplementary Figure 3B).
This interaction is supported by two AhR domains, one found in the cyclin D LXCXE motif and the other present within the transactivation domain of the receptor [ 47].
The strength and alignment of the EO/TO interaction is supported by a defined GC rich clamp sequence (GGCTG with respect to the EO).
Similar(48)
User interaction was supported by 3D visualisation of clusters and similarity measures.
The importance of this interface in PP2A-PTPA interaction was supported by mutational analysis described later.
The physical protein-protein interaction scores ranged from 0 to 5; 0 meant that the interaction was from none of these databases, while 5 meant that the interaction was supported by each of these databases.
Importantly, the specificity of each interaction was supported by the loss of fluorescent signals when using mutated or truncated Hox variants, and by the observation of typical nuclear interaction profiles with different TFs.
This interaction was supported by ICA that showed that miR-124 and Stat3 both have negative contribution from IC 1 (Additional file 2 and Figure 2C) correlating with an up-regulation in response to Pdx-1 induction.
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