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These data suggest that Wss1 functionally interacts with Top1, and this interaction is essential for clearing Top1-associated SUMO conjugates produced as a result of Tdp1 deficiency.
Msl3 and Hdac1 interact and it has been suggested this interaction is essential for the spreading of the DCC on the X chromosome[78].
TRADD directly interacts with TRAF2 at its N-terminal region, and this interaction is essential for cell survival through NF-κB signaling and efficient inhibition of apoptosis [12].
RalGDS interacts with Ras/Ral through RBD at its C-terminal, this interaction is essential for the Ras-dependent activation of its guanine nucleotides exchange activity.
CD98hc interacts with integrin β1 through the cytoplasmic and transmembrane domains and this interaction is essential for ES cell proliferation [ 9].
MLL1-WDR5 protein-protein istessentialis essential for MLL1 H3K4 methyltransferase activity.
Tat TAR interaction is essential for viral gene expression, replication and pathogenesis.
Understanding soil-geogrid interaction is essential for the analysis and design of geogrid-reinforced soil structures.
Importantly, USP15 BARD1 interaction is essential for HR and cancer cell response to PARP inhibitor (Fig. 2e, f and Supplementary Fig. 2c g).
Structure-guided mutational analysis shows that the Mmi1-Erh1 istessentialis essential for facultative heterochromatin assembly and for silencing of gametogenic genes.
Mitigating carnivore-livestock interaction is essential to ensuring the persistence of carnivores in landscapes dominated by livestock activity.
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