Moreover, we adopt an effective scoring strategy in ranking how likely the predicted proteins are interacting with each other by examining the interacting residues in the interaction interfaces.
To do this, we introduce iELM, a method to identify interactions mediated by SLiMs and add molecular details of the interaction interfaces to both interacting proteins.
This paper looks into identifying core building blocks for creating the ontology for human system interaction, interfaces, and integration.
In addition, another challenge is to clearly define the interaction interfaces among different modules, which may not be resolved by this LO-refinement procedure.
These polymorphisms were mapped to the structure of FGF18 to analyze possible effects on protein interaction interfaces or protein stability (Fig. 1C).
Then, 19F NMR chemical shift and relaxation data were obtained to analyze the interaction interfaces between MEKK3-PB1 and MEK5-PB1.
On Monday, July 1, the Museum of Modern Art's Senior Curator in the Department of Architecture and Design Paola Antonelli speaks about how a designer today can choose to focus on interaction, interfaces, the web, visualization, socially minded infrastructures, immersive spaces, biodesign, sustainability, video games, critical scenarios, and, yes, even products and furniture.
Our simple assumption behind extracting similar interaction interfaces from 3D Complex is that two structurally similar protein complexes are likely to have structurally similar interaction interfaces.
Another way to define the interaction similarity is through the similarity of the corresponding interaction interfaces.
The interaction interfaces between SecB and the two SecA protomers are obviously different.
As the result, we obtained 372 pairs of homologous interaction interfaces (Table 1).
