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Challenges of retrospective DUR programs include questionable clinical relevance of certain DDIs, poor evidence for many interactions, inconsistencies among knowledge bases and compendia, and incomplete patient data.
A significant species × site interaction would indicate inconsistency in species niche characteristics across sites.
§These designs do not contribute to the overall inconsistency interaction design × treatment (G.T).
The QTL × genetic background and QTL × environment interactions both induce inconsistency in estimated QTL effects (Bernardo 2008).
The design by treatment interaction model suggested no inconsistency in the network as a whole.
Non-independence between resistance and tolerance, or genotype-by-environment interactions may explain this inconsistency.
The internal validity of the network meta-analysis was assessed through interaction analysis modelling potential inconsistencies in the network.
Wide inconsistencies among interaction databases, pathway annotations, and the numbers and identities of nodes associated with a given pathway pose a major challenge for deriving causal and mechanistic insight from network graphs.
The model initially included these three main effects, as well as sample-date × sex and sample-date × age interactions, to test for inconsistency in the effects of sex and age across the two sample dates.
The extensive data begin to enable design against a spectrum of targets (polypharmacology); however, the data also reveal heterogeneities of structure, subtleties of chemical interactions, and apparent inconsistencies between diverse data types.
Moreover, users can improve the database quality by uploading their own interactions and indicating inconsistencies in the data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com