We have established two growth plate-derived chondrocyte cell lines, MMR14 and MMR17, from p53−/− mice (Nakamata T, Aoyama T, Okamoto T, Hosaka T, Nishijo K, Nakayama T, et al. In vitro demonstration of cell-to-cell interaction in growth plate cartilage using chondrocytes established from p53−/− mice. J Bone Miner Res 2003 18 97 107).
Studies bring out in a novel way the role of aliasing and other masked interactions in growth media factors.
These two inhibitors were used in a matrix of combinations, and an isobologram plot (Berenbaum, 1981) for IC50 demonstrated synergistic interactions in growth inhibition.
Understanding the contribution of genetic and environmental factors as well as their interaction in tree growth and adaptation is a prerequisite for accelerating tree domestication to meet the increasing demand for wood [ 1].
Interestingly, interactions between enhancers B, C and E with the MYC promoter were induced by serum mitogens suggesting that a subset of long-range interactions participate in growth factor stimulation of MYC expression.
Similarly, the carboxy-terminal peptide of p53 is able to abrogate mortalin-p53 interactions resulting in growth arrest in cancer cells [ 18].
Deciphering the complex interactions involved in growth factor-dependent and ovarian-steroid-dependent proliferation in the normal mammary gland has specific relevance to understanding the alterations in the growth control that occur in breast cancer.
Finally, more broadly, the finding of this work highlights the challenges involved in depositing homogeneous complex oxide thin films on the limited number of mostly lattice mismatched single-crystal substrates which are available and presents the case for use of suitable buffer layers to prevent deleterious chemical interactions in film growth.
There was clear evidence of among-deme differences (genotype - environment interactions) in larval growth and yolk-to-body-size conversion efficiency.
For example, SDL screening of the high osmolarity responsive kinase, Hog1, revealed no interactions in standard growth conditions but identified 74 SDL interactions when assessed in the presence of 0.2 M sodium chloride (Sharifpoor et al. 2012).
The mitochondrial currency of stored reduced molecules, NAD(P H, and its ratio to NAD + has been shown to have intimate interactions in the growth and metastasis of tumors.
