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A potential mechanism by which the MAP kinases mediate the effects of TGF-β1 is through the cell cell adhesion molecule N-cadherin, previously shown to mediate embryonic mesenchymal condensation, a requisite cell cell interaction in developmental chondrogenesis [ 106- 108].
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Future applications of this method to study the dynamics of RNA protein interactions in developmental and disease processes will help to further uncover the role of RBPs in post-transcriptional regulation.
In this spirit, here I report results from a series of computational experiments on mutational interactions in developmental regulatory network models that are specially relevant for early Drosophila embryogenesis (i.e. segment patterning).
Conversely, reduced system interactions, as in developmental dyslexia, yield impaired performance.
Through defining the nature and developmental origins of sexual dimorphism we provide a background for interpreting gene-environment interactions in directing developmental outcomes.
Taking together, these observations lead me to hypothesize that pervasive, and contrasting, epistatic interactions in actual developmental regulatory networks should be expected to arise, and that they may be naturally encoded in both their coupling pattern of feedback structures (regulatory architecture) and the complex emergent spatio-temporal expression trajectories.
The adequate assessment of different symptoms and deficits is especially important in adolescence since they can hinder important social interactions in this developmental stage [ 7, 9].
Given that HLOs are similar to human fetal lung, this tissue is an ideal model to study lung maturation of both the proximal and distal epithelium along with epithelial-mesenchymal interactions in a developmental context.
This suggests there is an interaction in vivo between developmental stage of cells and the composition of CSF.
The SAM domain is known to exhibit diverse protein-protein interaction modes, and is involved in developmental regulation [ 57].
However, the interactions among multiple signaling pathways in developmental context are complex and frequently a particular gene is regulated by more than one pathway or more than one gene.
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