This database is continually updated and supplemented with curated relationships taken from MEDLINE abstracts; i.e. each gene interaction held in the IPKB is supported by published information.
Moreover, the subset of expression samples where the regulatory interaction holds may be marked by presence or absence of a modifier gene, such as an enzyme that post-translationally modifies the TF.
In this way, examples of pseudopolymorphism, cocrystallization and water/anion tapes held by the interaction with the complex dimers are described.
In contrast, we argue that for the protein substrate used in our study, it is likely that the backbone conformation of the substrate will be held by extensive interaction of residues from P5 to positionsions.
The hydroxy group of the tyrosine moiety at the P2′ position of FII is held by direct interactions with the OD2 atom of Asp, and by weak interactions with the NZ atom of Lys.
This suggests evidence for two coexisting states for aromatic compounds in this size fraction, being held by intermolecular interactions of different strength.
Calculation of the values for the interplanar spacing for the (011) and (020) planes (d011 = 0.6021 nm and d020 = 0.5525 nm) shows that they are amongst the three most widely separated planes and are therefore likely to be held by weak interactions and parted easily.
The phenyl group at the P2 position of FII is held by hydrophobic interactions mediated through His and Tyr.
The triazole analogue binds to PDC in this cleft and is held by extensive interactions with the surrounding residues.
The phenyl side chain at the P1 position is held by hydrophobic interactions provided by the side chains of Phe and Val.
The C-terminal tyrosine side chain at the P2′ position of the inhibitor is held by hydrophobic interactions mediated through aromatic residues Phe and Phe, an orientation slightly different to that adopted by the tryptophan side chain of RXPA380.
