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At present, 308 RGS-protein interaction entries are deposited in RINGdb.
The automated BIND translation process found and removed interaction entries that did not meet minimum requirements as defined by MIMIx.
We inspected the supporting literature for a subset (10) of the interaction entries and in no case did the experiment design explicitly involve intra-nuclear compartments.
A new feature of this release is the cross-referencing of homeodomain protein protein interaction data to their respective BIND interaction entries.
Information can be linked to the genome from other databases, such as the Pathogen-Host Interaction entries [ 47] to efficiently access phenotypic information from pathogenicity testing involving single and multiple gene deletion isolates generated mostly in the reference strain PH-1.
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Annotation of a molecular interaction entry is traditionally based on a single publication that describes one or more experiments in which the interactions of the entry were determined.
With regard to format and data quality, ORegAnno tab-delimited flat files should be heavily parsed to remove non-human interactions, entries with missing information and gene name ambiguity; regarding the ORegAnno result page, it is broken into subpages containing a maximum of 10 TF-TG interactions each in which techniques used to detected the interactions are not displayed.
Blocking the interaction between entry receptors and gD inhibits HSV-1 entry and infection (Whitbeck et al. 1997; Geraghty et al. 1998; Shukla et al. 1999).
Electron cryomicroscopy studies of intact virions, recombinant virus-like particles, functional complexes, together with recent X-ray crystallographic studies on rotavirus proteins have provided structural insights into the capsid architecture, genome organization, antibody interaction, cell entry, trypsin-enhanced infectivity, endogenous transcription and replication.
The specificity of apotransferrin nanoparticles in cellular interaction and entry was assessed by competition of nanoparticles binding in both the presence and absence of mouse anti-human transferrin receptor monoclonal antibody (1 µg/0.5 million cells).
Furthermore, this strategy does not allow describing interdependencies between interactions across entries, because single binding events and their cooperative effects annotated in one entry cannot be referenced from another entry.
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CEO of Professional Science Editing for Scientists @ prosciediting.com