We normalized the number of interaction documents for each gene by the number of total interaction documents per year.
We compared genes underlying monogenic syndromes linked by 1, 2, or 3 path distances, with those with a path distance of 4 or that was unknown; unknown distances are those where no genes are associated with a syndrome, the syndrome is multigenic, or when DAPPLE has no known interaction documented, see 'Materials and methods'.
In 2013, the Toronto Star released a three-part investigation that found black people were disproportionately stopped and questioned, with their interactions documented by police, or "carded".
They looked for correlations among the 21,687 interactions documented between chaperones and their substrates, primarily proteins.
Then, the 'TF-gene' interactions documented in TRED and KEGG are directly deposited in RegNetwork.
Consequently, gene associations are ranked based on their conceptual relationships and not specific interactions documented in the literature.
We constructed an initial connectivity matrix to map the TF-gene interactions documented in AGRIS (Additional file 1, Sheet: Initial connectivity matrix).
It is important to note that (i) the list of interactions reported in the database is far from being exhaustive, (ii) the interactions documented are either physical or genetic, which implies that they may not be direct interactions.
Over the past several years, substantial efforts have been made toward the development of computational framework to predict protein protein interactions with the help of evolutionary information 9, 10 that are primarily based on experimentally known interactions documented in various databases.
