Sentence examples for interaction disruption from inspiring English sources

D577N disrupted the interaction by 30±10percentent, while an interaction disruption of 45 ± 10percentt was observed with a double mutation of D577, 578 N.

Another hurdle is the lack of chemical libraries meeting the structural requirements of protein-protein interaction disruption.

This novel Sequential ChIP protocol provides a significant improvement from previously described Sequential ChIP assays by combining two methods of physical separation of the targeted DNA (centrifugation and magnetism) and avoiding antibody-antigen interaction disruption during the assay.

The initial disruption of lignin-arabinogalactan/pectin in concert with other changes (some lignin-xylan interactions disruptions and the loss of arabinogalactans) that occurred in the cell wall were associated with an increase in digestibility of up to 24% as compared to the untreated material, depending on enzyme loading.

In general the mechanisms of action against bacteria are attributed to the interaction and disruption of the bacterial membranes [15].

Applying those findings, we had established a cell-based flow cytometric high throughput screening (HTS) platform for isolation of small molecules causing inhibition of 2C T cell absorption of LdB7-1ICAM-1 pMVs, whicancan be exerted by either physical interference of TCR/pMHC or LFA-1/ICAM-1 interactior or disruption of TCR-mediated 'inside-out' signaling [15].

An Asp at position 67 would likely perturb the Pikp-HMA/AVR-PikD interaction through disruption of this salt-bridge.

The increased doses of R2 increased dissociation constant KD of FAK and p53 protein interaction, supporting disruption of FAK and p53 complex by R2 in a dose-dependent manner.

Moreover, elimination of both potential allelic interactions and one, but not both, possible pix6-vix6 nonallelic interaction by disruption of pix6-2 and vic6-1 or pix6-1 and vic6-2 allelestillll allowed barrage formation but resulted in an asymmetric, allele-specific, loss of resistance to virus transmission (Table 5, pairings H and I).

If the target residues within the putative contact site are essential for the interaction, their disruption will expose mAb epitopes normally obscured in low detergent buffer, similar to treatment with partially denaturing buffer (Fig. 1). Figure 4 shows how mutations can expose antibody epitopes that are normally obscured.

Buffering salts in the mobile phase can decrease these electrostatic interactions through disruption.