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"If we can normalize the hypersensitivity to touch, it's possible that this might help improve anxietylike behaviors and social interaction deficits.
The social communication and interaction deficits associated with the autism phenotype can have serious emotional consequences for individuals on the autism spectrum.
Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats.
On the other hand, DGKβ KO mice did not show schizophrenia-like behavioral changes, as typified by PPI and social interaction deficits (Figure S3).
By contrast, Iwata et al. [37] observed social interaction deficits in animals subjected to irradiation of the entire forebrain, leading to various undesirable side effects.
Autism (MIM 209850) is a phenotypically and etiologically heterogeneous disorder of childhood characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and restricted interests and repetitive behaviors.
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Cariprazine (0.3 mg/kg) caused a limited reversal of the social interaction deficit but neither drug affected the change in USVs or the deficit in fear motivated learning and memory.
Three defining clinical symptoms of autism are aberrant reciprocal social interactions, deficits in social communication, and repetitive behaviors, including motor stereotypies and insistence on sameness.
The diagnosis of ASD is based on a triad of core symptoms, namely qualitative and quantitative alterations of social interactions, deficits in communication, and the occurrence of repetitive/perseverative behaviors [13].
The ability to process faces is crucial in our daily social interactions; deficits in this ability lead to debilitating social consequences as in the case of autism or prosopagnosia.
Violent behavior by individuals with ASD has been noted as early as 1944, when Hans Asperger(p 40) described the case of Fritz V., a boy with severe social-interaction deficits who would quickly lash out at peers "with anything he could get hold of (once with a hammer), regardless of the danger to others".
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