"If we can normalize the hypersensitivity to touch, it's possible that this might help improve anxietylike behaviors and social interaction deficits.
The social communication and interaction deficits associated with the autism phenotype can have serious emotional consequences for individuals on the autism spectrum.
Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats.
By contrast, Iwata et al. [37] observed social interaction deficits in animals subjected to irradiation of the entire forebrain, leading to various undesirable side effects.
On the other hand, DGKβ KO mice did not show schizophrenia-like behavioral changes, as typified by PPI and social interaction deficits (Figure S3).
Autism (MIM 209850) is a phenotypically and etiologically heterogeneous disorder of childhood characterized by impairments in social interaction, deficits in verbal and non-verbal communication, and restricted interests and repetitive behaviors.
The major findings of the present study are that fractionated ionizing irradiation to the adult male rat brain causes schizophrenia-relevant abnormal behaviors (e.g., methamphetamine-induced hyperactivity, sensory motor gating deficits, social interaction deficits, and working memory deficits) at three months after the irradiation.
These mice have a reduced brain size, sensory gating deficits, social interaction deficits and cognitive impairments.
It has been argued that basic social interaction deficits in cocaine users may arise from altered social reward processing [ 31].
Furthermore, the PPI and social interaction deficits noted in the Bdr mutants were markedly modulated by PNS.
