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The main purpose of this study is to identify putative drug targets for human sperm-egg interaction deficiency and consider if the detected essential proteins are targets for any known drugs using protein-protein interaction network and ingenuity pathway analysis.
These results showed that the drugs ocriplasmin (Jetrea©), gefitinib (Iressa©), erlotinib hydrochloride (Tarceva©), clingitide, cetuximab (Erbitux©) and panitumumab (Vectibix©) are possible candidates for efficacy testing for the treatment of sperm-egg interaction deficiency.
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Anemia in heart failure is considered to develop due to a complex interaction of iron deficiency, kidney disease, and cytokine production, although micronutrient insufficiency and blood loss may contribute.
In contrast, wild-type littermates did not display NTDs when folate deficient, suggesting that NTDs in the mutant embryos resulted from an interaction of folate deficiency with NTD predisposition, imposed by loss of Pax3 function.
Unfortunately, neither hA53Tα-syn [51] nor hA30Pα-syn mice provided evidence for interaction between Parkin deficiency and synucleinopathy in catecholaminergic brainstem neurons (Figure S2, Table S1).
The interaction between micronutrient deficiency, infection, and immunity has been well documented.
We found no indication of interaction between immune deficiency and smoking.
It has been suggested that apathy may reflect an interaction between cholinergic deficiency and subsequent neurological changes in limbic regions [ 42].
The interaction of VE deficiency in diet and exposure to radiation could break the equilibrium of oxidation and antioxidation and result in IGT.
This study has proved that oxidative stress may be an incentive of IGT with the fact that the latter was induced by the interaction between VE deficiency in diet and exposure to radiation.
It is important that clinicians understand the interaction of iron deficiency, anaemia, renal dysfunction, and chronic HF, and development of more accurate terminology to describe specific combinations of these adverse phenomena may be one step towards improving awareness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com