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To study the enrichment of physical interactions within the pathways identified by our method, we downloaded the physical interaction data collected by Ulitsky and Shamir [8], which included 67,856 physical interaction pairs.
Finally, our score schema is validated by using drug interaction data collected from the GEO.
To create a model for T2D genetic risk gene molecular systems structure, we built a gene interaction network seeded by T2D risk genes collected from T2DGADB and expanded with high-confidence protein interaction data collected from the Human Annotated and Predicted Protein Interaction database (HAPPI) [ 14].
We have also checked the results for the protein protein interaction data collected by the yeast two-hybrid experiment and we found that both protein connectivity and protein complexity are positively correlated with gene duplicability (R = 0.132, P < 0.001; R = 0.208, P < 0.001), respectively.
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Human social interactions data collected from mobile phones have been identified as potent stressors which often impact his/her social behavior [24].
Then, we proceeded to test our approach on high-quality experimental protein-protein interaction (PPI) data collected from five databases.
All yeast protein protein interaction data were collected from Li et al., where protein protein interaction pairs were collected from various high throughput experiments and databases.
Protein-protein interaction networks were generated using selected sets of genes from the enriched GO categories and high confidence interaction data were collected by diverse experimental methods available at the human protein reference database (HPRD) [22].
Binary protein protein interaction data were collected from the Human Protein Reference Database (HPRD Release 9) (Prasad et al. 2009).
Next, a table summarizes all of the interaction data we collected, including experimental observations and additional comments.
Human protein interaction data were collected, extracted, and integrated from the HPRD [ 11], BIND [ 20], MINT [ 21], STRING [ 26], and OPHID [ 25] databases, using data warehousing techniques.
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