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Most bands disappeared, showing that a large fraction of SAF-B is recruited via direct interaction with RNA, or through some RNA-mediated protein-protein interaction, consistent with the RNA-dependent high-molecular-weight complexes in human cells[20].
Several additional observations suggest that the severity of phenotypic traits of coronin-1A deficient T cells varies proportionally to the affinity of TCR-ligand interaction, consistent with the view that coronin-1A impacts on TCR signaling potential.
Finally, we used MetaCore from GeneGo, Inc. to model a gene-by-environment interaction consistent with the data.
Forty-four of the 58 genes assessed (75%) displayed a modulation of expression during the onset of the interaction, consistent with the results of array hybridization.
The orientation of the two helices and their hydrophobic interactions is mainly mediated by leucine residues and resembles a leucine zipper interaction, consistent with the predicted CC propensity of STIL-CC (Stevens et al., 2010).
Of the 128 genes screened with two independent dsRNAs, only 8 showed an interaction consistent with the HFA genome-wide data, with a further 4 trending in the right direction (Additional file 5).
Similar(52)
The obtained computational results suggest that the compound 3a can act as a dual inhibitor of MDM2 p53 and MDMX p53 interactions, consistent with the experimental results.
Surprisingly, we found that the mutation induces a change in the conformation of a nearby surface loop resulting in stronger lattice interactions, consistent with the improved crystal quality.
Destabilisation of p53 tertiary structure induced protein aggregation through hydrophobic interactions, consistent with the notion that wild-type p53 contains a hydrophobic core which may become exposed by metal chelation.
This suggests that the Dpb11 Mec1 interaction is functionally dependent on the Dpb11 Ddc1 interaction, consistent with 9-1-1-dependent recruitment of Dpb11.
The yeast cells expressing both NaTOC1 and NaZTL constructs grew well in the absence of leucine, tryptophan, histidine, and adenine, showing the positive interaction, consistent with Arabidopsis TOC1 and ZTL interaction.
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