Exact(10)
Recall that the overall interaction conservation rates between S. cerevisiae and S. pombe are 18.11%/22.18%.
Different rates of protein-protein interaction conservation depending on sequence similarity have indeed been documented recently [ 51].
This method (GO clustering) is in contrast to our alignment-based combined method, which makes use of interaction conservation.
We showed that good results can only be achieved when using a proper definition of interaction conservation and when treating large CCS in an adequate manner.
Van Dam and Snel [ 17] showed that conservation rates for PPI within complexes in human and yeast are much higher than overall interaction conservation.
In contrast to these databases, interactions in MPIDB are further supported by 8150 additional evidences based on interaction conservation, co-purification and 3D domain contacts (iPfam, 3did).
Similar(50)
An analysis of all known structures of proofreading domains in complex with post-transfer substrate analogs helped us to define certain parameters such as percentage buried surface area of the ligand, number of interactions, conservation of interacting residues etc that can be used to assess the binding characteristics of ligand complexes.
Increased knowledge about the interaction between conservation of natural resources, influence of forest, conservation of water availability in the catchment and perception of local peoples' participation in conservation activities are integrated components (Schmithüsen and Wild-Eck 2000; Dolisca et al. 2007).
Conservation across eukaryotes of Mediator structure, subunit organization, and RNA polymerase II interaction suggest conservation of fundamental aspects of the Mediator mechanism.
A study comparing worms and yeast concluded gene interaction lacks conservation [ 40], whereas studies comparing evolutionarily divergent yeast have found that substantial conservation exists [ 41, 42].
This paper presents an historical perspective on the interaction between conservation science and policy.
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