This further suggests that while the strength of inhibition observed on plates in vitro reflects, and may inform on the presence of antagonistic microbial interactions, caution should be taken when drawing conclusions based on the exact extent of antagonism in vivo.
Despite the absence of documented metabolic drug interactions, caution is to be exercised with known substrates of P-gp (quetiapine, risperidone, olanzapine) and DAAs.
The text was divided into four sections: contraindications, drug interactions, cautions for use and adverse effects.
Documents consisted of paragraphs corresponding to one or a few contraindications, drug interactions, cautions for use or adverse effects.
One or more icons can be combined with a few grammatical elements to build simple medical sentences expressing contraindications, drug interactions, cautions for use or adverse effects.
The various concepts that can be involved in contraindications, drug interactions, cautions for use and adverse effects, including diseases, drugs, procedures, patient characteristics e.g. age, or lifestyle, e.g. alcohol consumption, were determined using our expertise and published models [ 9].
The concepts have been graphically represented using the icons of the VCM language [ 8], that we initially developed for the representation of the various contraindications, drug interactions, cautions for use and adverse effects of drugs.
For the evaluation, we compared the "Mister VCM" graphical interface to a textual interface which organizes the text into four sections: contraindications, drug interactions, cautions for use, adverse effects.
When the physician wants more details about contraindications, drug interactions, cautions for use or adverse effects related to a given anatomical or functional location or etiology, he may click on the corresponding VCM icon to obtain the complete information (the yellow rectangle on the right, in figure 2).
