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For example, assessing interaction can be problematic in many real-world epidemiologic studies given the primary concern with bias and confounding.
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Especially for moderate-sized populations, the interactions can be problematic, leading to very large segments in the genome raising together in frequency (Supplementary Fig. S12).
When presenting the statistical results we start with the main effects and continue with interactions, which can be problematic in case of strong interactive effects.
More accurate quantification requires isolation and HPLC separation of the various phenanthridiniums[ 2] as so-called exomarkers.[ 22] Here, the interaction with DNA can be problematic because it adversely affects extraction of the phenanthridiniums from the biological medium and so makes quantification less reliable.
However, there are sometimes limited options available and drug interactions and toxicity can be problematic, and prevalence of resistance in Candida 10 and Aspergillus 11 is increasing.
Clearly, directly inducing widespread modifications to expression levels of many regulatory components, or of the interactions between many such components, can be problematic.
Here, we argue that proportionality of hazards can be problematic in competing-risk problems and analyses must consider time by covariate interactions as a default.
However, CDS can be problematic.
The results can be problematic.
Displaying insects can be problematic.
"Two days can be problematic.
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