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They emphasize the advantage of a one-dimensional approach to solve the problem of this interaction, analyzing the shadows projected by these elements from a side view.
In the case of host-pathogen interaction, analyzing the differential interactions in a time-dependent manner can show how the host attempts to respond to the pathogen and how the pathogen responds within the host [ 16].
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Huard, B. et al. CD4/major histocompatibility complex class II interaction analyzed with CD4- and lymphocyte activation gene-3 (LAG-3)–Ig fusion proteins.
An interaction analyzed by Chou and Talalay method provided an assessment of cytotoxicity scale affected by combined use of silybin and lasalocid.
However, given the large number of interactions analyzed (n = 364), none of these P values remained significant at a P level of <0.05 after Bonferrroni correction.
NR2E3/CRX interactions analyzed by BRET2 also showed the importance of a freely accessible N-terminal DBD of CRX to interact with NR2E3.
None of the seven interactions analyzed was replicated.
Predicted binding poses were visualized and ligand protein interactions analyzed with LigandScout 3.03 (www.inteligand.com).
The methods are discussed in depth with particular reference to MS-based approaches for analyzing protein protein and protein immobilized ligand interactions, analyzed either directly or indirectly.
Interactions between RFX7 and other genes were not observed, which is likely due to the incomplete coverage of the human protein-protein interactions analyzed in this study.
The drug interaction study was analyzed with Calcusyn 2.0 software.
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