In the latter high-confidence network ("TPA HCI"), 576 proteins of T. pallidum are connected by 991 distinct interactions with an average of 3.4 interactions per protein.
In the most recent release 7 of the Human Protein Reference Database (HPRD) [ 11], there are only 38,167 protein interactions reported – an average of only 1.5 interactions reported for each of the 25,661 human proteins included in HPRD.
A total of 28.5% of all additive QTLs were involved in epistatic interactions, and an average of 0.7 pair-wise interactions were found per study.
For the eight genes for which we replicated independent interactions with the v-eQTL, we found that in total up to 10.4% of the variance was explained by these multiple interactions, with an average of 5.1%.
The interaction network generated from the Low Extracellular ATP group shows a high degree of connectivity with an overall average of 2.03 edges/node, and comprises a unique module including 70% of the mapped Low ATP genes with only direct interactions, with an average of 2.19 edges/node.
The detector is designed to operate at high interaction rates with an average of 4 5 interactions per event.
It is worth noting that the Hi-C data sets used in this work were generated from a population of cells rather than a single cell such that the gene-gene interaction data is an average of the spatial interactions of a population of cells whose genome conformation may vary.
Calculations at the VDZ-F12 level underestimate the CBS interaction energy by an average of 0.61 kcal mol−1, VTZ-F12 by 0.36 kcal mol−1, and VQZ-F12 by 0.13 kcal mol−1.
NBO analyses reveal highly polarized U As interactions that comprise an average of 91.3 % As and 8.7 % U character, and these interactions are also found at the second-order level of perturbation.
In these β-sheet interactions, strands made an average of ten hydrogen bond acceptors and donors available to the partner protein, with two-thirds of the carbonyls and amide N H's participating in hydrogen bonding.
