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To account for these different routes, and to evaluate their effects on the evolution of modularity, we run additional simulations where single interaction additions are simulated as protein recruitment or formation of interaction among existing proteins with a certain probability.
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For high interaction addition rates and low interaction deletion rates, SPICi has better overall performance than MCL.
In the former method, interaction addition and deletion is assumed to occur only immediately following a duplication or speciation event.
The heuristic also can be extended to handle different costs for interaction addition and deletion by changing the constants in the recurrences to be a function of the parity of each flip.
Analyzing the effects of different mutational processes on pathway structure, we find that transitions from modular pathways to pathways with crosstalk are extensively caused by interaction addition (data not shown).
He is that very rare thing, a geek who can use his right brain (social interaction), in addition to his left (computer code).
They include sensory balance and being able to control privacy and social interaction, in addition to having choice and independence, clarity and predictability, and access and support in the neighborhood (to name a few).
This may reflect increased ionic interaction upon addition of an extra positive charge in this position.
In light of the earlier discussion, the bidirectional interaction in addition to common input could also contribute to the observed near-zero phase-lag.
This introduces the possibility for another mode of POM protein interaction in addition to the demonstrated electrostatic interaction.
The commonality suggests that the sp carbon network contributed to the amine GO interaction in addition to the oxygen groups.
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