Sentence examples similar to interacting with high affinity from inspiring English sources

Finally, 6 and 16 interacted with high affinity with trypanothione reductase (TR), an essential enzyme for the leishmanial parasite and compound 6 inhibited TR with sub-micromolar potency.

Computational docking and molecular dynamics simulation (MDS) showed that OPB-31121 interacted with high affinity with the SH2 domain of STAT3.

Isothermal titration calorimetry experiments showed that the insoluble complex contains 12 trypsin molecules per MMA molecule at pH 5 and they interact with high affinity to form insoluble complexes.

Our in vitro results demonstrate that recombinant Cyr61 interacts with high affinity to immobilized multimeric or monomeric VTNC.

We next asked if the S100B oligomers retain their binding affinity and stoichiometry for target peptides that are known to interact with high affinity with the S100B dimer.

Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity.

Further, VTNC interacts with high affinity with type 1 plasminogen activator inhibitor (PAI-1), the primary serine protease inhibitor (serpin) of both tissue- and urokinase-type plasminogen activators, leading to attenuation of fibrinolysis [12], [13].

An aspartate in position W+1 seems to be conserved in all the ULM ligands known to interact with high affinity to UHMs in which the X of the Arg-X-Phe motif is an aromatic (i.e. Y or W) instead of a positively charged residue.

These results suggest that the monomers of AdoMetDc interact with high affinity.

Guanine nucleotides interact with high affinity to GTPases due to a conserved DXXG motif in the G-domain.

Previous work has revealed that the Ubl domain of Parkin interacts with high affinity with the C-terminal catalytic domain [ 23].