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Modifying the interactor proteins causes structural changes that manifest themselves on the interacting surface of the target protein and these changes are monitored using in-cell NMR.
Thus, to date the biological function of the histone H3 interacting surface of the G9a ANK domain is unknown.
The interacting surface of the gp5 E-loops has mostly negative charge, in contrast to the mostly positive charge as in BPP-1.
The interacting surface of the three gp5 molecules has more positive charge, in contrast to the mostly negative charge as in BPP-1 MCP.
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The STINT-NMR spectrum of Ubiquitin interacting with phosphorylated STAM2-Hrs reveals changes in chemical shifts for a number of residues (Fig. 2d) and the loss of the interacting surface attributed to the VHS domain of STAM2 (Fig. 3f).
The 'part behavior' is achieved through a set of spatial and design functional relationships between the interacting surfaces of the parts.
Inevitably, this leads to decreasing oil film thicknesses between the interacting surfaces of these components and a more crucial role for the topography and surface profile of the two surfaces in determining tribological performance.
In case of the diesel engine, the optimal control of interacting surfaces for improving the performance of engine becomes important more than before, especially in designing the surfaces of cylinder liners.
The WVF motif is likely located outside this N- and C-terminal interaction region and may be important for formation of the interacting surface with ETO1.
Tryptophan 142 (W142) in GLTP has been proposed to be part of the membrane interacting surface and would exhibit shallow intrusion into the membrane bilayer [16].
The enhancement is attributed to formation of vortices that induce a thinner boundary layer over part of the interacting surface footprint.
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