The lack of a rigid 3D structure in IUPs is thought to provide several functional advantages, including conformational flexibility to interact with multiple targets, increased interaction surface area, and accessible post-translational modification sites [ 4, 5].
The release of drug decreased with increasing adsorbent particle size because of entrapment of drug in deeper voids of larger particles and a narrow surface area interacting with aqueous dissolution medium (Sohn et al. 2012).
However, pairwise mutations of these residues had only modest effect on the affinity; this suggested that Jac1 and Isu1 may interact over a broad surface area.
Overexpression of Sdpr in cultured cells leads to caveolae elongation and perhaps results in an increased surface area for interacting cell signaling molecules.
In fact, the maximum PCE observed at N LP = 40,000 is thought to result from a synergetic combination of both low work function of the CEs (improvement of catalytic activity through a favored electrons transfer to the electrolyte solution) and their high surface roughness (large effective surface area to interact with the electrolyte).
Binding of Ca2+ to CaM regulates CaM's binding activity by modulating the amount of exposed apolar surface area available to interact with various CaM binding substrates.
In PABP, the RRM domains interact burying 550 Å of surface area to form a narrow binding trough capable of directly threading nucleic acid from the second RRM domain into the first.
PDIviz identifies surface areas interacting with different regions of DNA, namely DNA bases, the sugar-phosphate backbone, and the major and minor groove.
Yeast Mediator contains 25 subunits arranged in four modules designated as "head," "middle," "tail," and "kinase" (Poss et al., 2013) and interacts with Pol II over a large surface area.
Here, we demonstrate that GRG interacts with gal-1 over a large surface area on the protein that includes the quintessential lactose-binding site and runs from that site through a broad valley or cleft towards the dimer interface.
