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FBDD is an emerging modular approach to drug design aimed at deriving high-affinity ligands starting by identifying weakly interacting small molecular fragments (<300 Da).
The curation process involved reading scientific articles (abstracts and full texts) to ensure that the correct action type was assigned to the interacting small molecule and then transferring the data of interest into an electronic form.
Our analyses considered three cases: one neuron with two weights and two stimuli, one neuron with two weights and three stimuli, and lastly a weakly interacting small network of neurons.
Possible methodological caveats could be the Beavis effect (Beavis 1998) where through interacting small sample sizes and low heritability values major QTL are quickly overestimated, leaving smaller QTL undetected.
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In the case of RIM and Rabphilin, the zinc finger domain has been demonstrated to interact small synaptic vesicle membrane-associated GTPases (Rab3 and Rab27) via the zinc finger region (Wang et al. 2001).
In this area, there are reports of sea turtles interacting with small-scale fisheries.
The companies inside Tornante are already interacting in small ways.
In both courses, students were regularly doing work where they were interacting in small groups.
Google would probably also like people to get comfortable with the idea of wearing and interacting with small devices, since -- have you heard?
The V-ATPase itself can act as a pH sensor, interacting with small GTPases in an acidification-dependent manner to modulate vesicular trafficking [3], [54], [55].
This concentration is not surprising considering that their mode of action consists of interacting with small metabolites to regulate the expression of genes involved in tRNA aminoacylation and in transport and biosynthesis of amino acids [26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com