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Overall these findings point to distinct Ca2+ sensitivities that are determined by two probably interacting sites within the IML2 of UCP3.
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To identify regions that are frequently associated with the bait region other than random collision, we applied statistical models to analyze interacting sites within each chromosome.
In contrast, allosteric modulation between two simultaneously bound and interacting sites, either within a receptor monomer or across a receptor dimer/oligomer, can alter ligand dissociation (6).
All the interacting sites within ±1 Mb range of a positively interacting site were clustered as an enriched interacting domain.
As the freely varying sites mutate, however, interacting sites can switch between variable and invariant states.
With the exception of miR399d, all miR399 members cleaved both interacting sites 2 and 5 (miR399d cleaved interacting site 2 only).
Up-regulated ATF6, ATF4 or XBP1S expression induces apoptosis by interacting with binding sites within the promoter of the CHOP gene.
This monomer is particularly useful because it contains in the same structure different functions that may interact with different sites within the same protein (by ionic interaction of hydrogen bonding).
For most of the known miRNA/target mRNA pairs the miRNA is predicted or known to interact with multiple sites within the 3' UTR [ 23- 28].
Recently, we reported two crystal structures of a bacterial POT family transporter, PepTSt, from Streptoccocus thermophilus, which revealed di- and tri-peptides interacting differently within the binding site (Lyons et al., 2014).
Although this motif has ligand attributes, it is not within the previously characterized interacting sites.
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