An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism.
It is sometimes possible to infer a relatively larger number of potentially interacting proteins, which may not have enough evidence to be confirmed as true positive labels.
In this yeast two-hybrid study, we identified the serine/threonine phosphatase PP1β as a BRCA1 interacting protein, which could have important consequences on both the activity of BRCA1 and the regulation of PP1β activity.
Activin-receptor interacting proteins (ARIPs), which have PDZ domains, associate with the COOH-terminus of ActRIIs and regulate activin signaling.
Our microarray data confirmed the lower expression in HVC of several members of the ionotropic and metabotropic glutamate receptor family (GRIA4, GRIK2, GRM1, GRM5) and the higher expression of a splice variant of glutamate receptor interacting protein 1 (DIP2A), which has known glutamate receptor binding activity.
We describe the identification and initial characterisation of a new Pex3-interacting protein, which we have named Atg36, as it is required for pexophagy in S. cerevisiae: its overexpression induced pexophagy, and its absence prevented pexophagy.
Additionally, calcineurin B-like (CBL -interacting protein kinase, whiCBL -interactingerine/threonine kinase activity, has been reproteinto be involved in the defense response to fungus [ 44].
It has just one interacting protein, which is another DNA mismatch repair protein Mlh1 (Q9JK91) that is also involved in somatic hypermutation [ 105].
In accordance, we also observed an increased expression of MLX-interacting protein (MLXIP), which has been suggested to be an essential regulator of cellular glycolysis [ 35].
In particular, it was found that apoptosis-linked gene-2-interacting protein X1 (AIP1), which has now been identified as a potential N. fowleri pathogenicity factor (Table 4), is a key regulator of endosomal sorting [ 32].
