To help consolidate the literature and determine if there are any similarities between the RBRs and their interaction partners, we have assembled a comprehensive table of RBR interacting proteins that have been identified using direct experimental methods (Table 1).
To accomplish this, we assembled a new compendium of interacting proteins that are interrelated, and not limited to known inflammation biomarkers in post-MI.
Interpretation of interacting proteins that are not likely to interact in functionally relevant ways with target proteins is a caveat in current proteomic methods.
We conclude that Evc and Evc2 are interacting proteins that together modulate Hh signal transduction.
Indeed, the definition of the hypergeometric clustering coefficient assures a high score for interacting proteins that share a lot of their interaction partners.
In addition to the intramolecular forces and bonds, ions, cofactors and interacting proteins that stabilize soluble proteins, membrane proteins are usually interacting with and are partially also stabilized by the lipids of the surrounding bilayers (Adamian et al. 2011).
We used the network to study the set of interacting proteins that are encoded by genes co-expressed during sporulation.
Therefore, we wished to establish a comprehensive list of ING interacting proteins that would aid in the understanding of the complex role of this family of tumor suppressors in regulating diverse cellular functions.
When proteins interact, the binding interface of the interaction is generally localized to specific conserved segments of the interacting proteins that are broadly known as domains.
We follow this evaluation by then predicting co-evolved residue pairs of interacting proteins that have no known complex structure.
We therefore performed an in situ proximity ligation assay (PLA), which detects interacting proteins that are in close proximity, within 30-40 nm of each other, and allows for a quantitative analysis of these interactions.
