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The obtained results show that mutations alter the flexibility and the coordination properties of the native state, with a specific impact on the dynamics of the α2-α3 hairpin hairpin, which in turn modify the protein interactive surface impinging on the binding sites for conversion inhibitors and activating the interacting properties of the β2-α2 loop [Figure 6].
DNA binding studies were also revealed strong interacting properties of triazine derivatives towards calf thymus-DNA.
In this case, the interacting properties of V210I and R208H could be approximated to that of the sulfoxidized proteins, which importantly overlaps the common pattern identified for the rest of the mutations.
In addition, the rDNA now appears not only as an intra-chromosomal insulator region, but also modifies the interacting properties of the two DNA segments it delimits.
Other synthetic and natural polymers, both with and without hydroxyl-functional side chains, showed negligible activity, highlighting the unique ice/water interacting properties of PVA.
Chakrabartty and co-workers [ 38] showed that only small deletions in an AFP with repetitive structure from flounder altered the ice interacting properties dramatically.
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This biological interacting property helps in the early detection of diseases such as cancer, diabetes and neurovascular disorders.
There is some evidence related to the DNA interacting property of Acridine ring containing compounds that limit its widespread use.
Although KLK has been reported to have a profound membrane interacting property [24], it shows further effects: KLK activates human neutrophils [25,26], exhibits chemotherapeutic activity [27], is a potent inducer of adaptive immunity to co-injected antigens [28] and leads to a fast increase of intracellular calcium levels [29].
In this study, we describe an in silico method to design peptides that can be made of non-natural amino acids and elicit specific membrane-interacting properties.
Whereas P. avidum and P. granulosum produce an EPS-like surface structure and pili-like appendices, respectively, P. acnes possesses a number of unique surface-exposed proteins with host-interacting properties.
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Justyna Jupowicz-Kozak
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