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In several cases, results were spurious due to confounding and interacting predictors within the same model.
This first-time data mining analysis with 'data cloning' and machine learning methods (boosted regression trees) shows how to extract the major signals in this unique dataset from highly correlated and interacting predictors.
Potentially interacting predictors included contexts internal and external to the practices and mechanisms, both part of the intervention (eg elements of facilitation) and external influences.
RF allows for the identification of multiple interacting predictors and identifies which of these are most important without imposing a structure or model on the way that it takes place.
The discovery method leveraging interaction plots and the linear contrast can be used to scan pairs of predictors to quickly find potentially interacting predictors, and the 4-machine estimation method can be used to estimate the interaction effects for those interacting predictors.
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The protein interactions considered include all protein pairs predicted by the human protein-protein interaction predictor PIPs to interact with a posterior odds ratio above 4 [ 37, 38] as well as protein pairs annotated as interacting in HPRD [ 31] and IntAct [ 39].
For predictors interacting with continuous variables, the hazard ratio at the median of each continuous variable is presented.
A separate slopes model is used in the former case, as a traditional analysis of covariance (ANCOVA) is inappropriate when the categorical and continuous predictors interact in influencing responses on the outcome [31].
As diagnosis interacted with other predictors, regression analysis was stratified for fractures and osteoarthritis (Table 3).
Otherwise, only one pair of predictors interact (change substantially in predictive power when both are included): |ΔDAF| and Fst.
Firstly, by identifying profiles, the study explored how the effects of predictors interacted, suggesting that their interplay rather than their isolate effects are decisive in differentiating professionals with regard to stress reactions (IES-R score).
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