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Stories of people interacting physically with art works tend to be tragic, whether they be the hammering of Michelangelo's Pieta or that clumsy kid who tripped and punched a hole in a 17th century painting.
Motor imitation, that is, the possibility of interacting physically with others by sharing a behavioural state, represents a powerful biological resource for cognitive development [1] and social interaction [2].
Zhou and colleagues recently extended these observations by demonstrating that the sorting nexin LST-4 also functions at this step, interacting physically with DYN-1 and promoting the fusion of the maturing phagosomes with endosomes and lysosomes [19].
Tax activates NF-κB by interacting physically with NEMO.
More importantly, we show that β3 integrin regulates TGF-β signaling by interacting physically with TβR-II and stimulating its phosphorylation on tyrosine residues by Src.
We recently discovered that CystC antagonizes TGF-β signaling in normal and cancer cells by interacting physically with TβR-II, thereby preventing TGF-β binding [ 12].
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Prp2 and Spp2 interact physically and the interaction is necessary for the activation of Prp2 function [ 42, 44].
Consistent with this, we observed that, in zebrafish, Nhsl1b and Scrib interact physically and exhibit a strong genetic interaction.
Here, a functional interaction refers to pairs of proteins that interact physically or belong to the same biological pathway.
Which is very similar from the human interaction perspective, this is what we see when we interact physically".
In the presence of Ca2+, SOS3 interacts physically with the regulatory domain of a calcineurin B-like-interacting protein kinase (CIPK), SOS2/CIPK24 [51].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com