Sentence examples for interacting mediator from inspiring English sources

Here, we show that two pro-apoptotic members of the 'Bcl2 homology domain 3-only' subgroup of the Bcl2 family, Bcl2 interacting mediator of cell death (Bim) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI-Ig overexpression that effectively neutralizes BAFF as well as APRIL.

Phosphorylation of the MAPK site is accompanied by a conformational change in the protein, exchange of interacting Mediator components, and transcriptional activation (Mo et al, 2004).

This gene, known as the guardian of the genome, stimulates other proteins such as p53 upregulated modulator of apoptosis (PUMA), Bcl-2 interacting mediator of cell death (BIM), and NOXA to initiate the cell death cascade [ 38– 40].

Dysregulation in DC apoptosis, whether through over-expression of pro-survival Bcl-2 proteins or loss of the pro-apoptotic protein, Bcl-2 interacting mediator of cell death (Bim), can trigger autoimmune disease, tumorigenesis, and prolonged immune responses.

It has been reported that when cultured in suspension, some anoikis-sensitive cells induce the expression of the BH3-only proteins B-cell lymphoma 2 interacting mediator of cell death (Bim) or Bmf.

Regulation of Bcl-2 interacting mediator (Bim) in response to hypoxia presented a more complex pattern of regulation with an accumulation of the protein at 1 2 h of treatment (Supplementary Figure 4) and a second peak of induction at 48 h.

Firstly, the present Bayesian networks are necessarily incomplete by virtue of the fact that they do not contain the entire array of possible interacting mediators.

The biological mechanisms underlying the association between obesity and breast cancer survival are not established, and could involve interacting mediators of hormones, adipocytokines, and inflammatory cytokines which link to cell survival or apoptosis, migration, and proliferation [ 9].

Our results provide evidence that simvastatin-induced apoptosis is mediated by GTP loading of unprenylated Rho GTPases, and involves the intermediacy of JNK-mediated Bcl-2-interacting mediator (Bim) activation, downstream of intracellular superoxide production.

Activator BH3-only proteins were not required for apoptosis induction as apoptosis was unaltered in the absence of all BH3-only proteins known to activate Bax or Bak directly, Bcl-2-interacting mediator of cell death, BH3-interacting domain death agonist and p53-upregulated modulator of apoptosis.

Bcl-xL also interacts with voltage-dependent anion-selective channel protein 1 (VDAC), Bcl-2-interacting mediator of cell death (Bim), DMN1L (dynamin-1-like protein), Becn1 (beclin-1), PGAM5 (phosphoglycerate mutase 1), PUMA (p53 upregulated modulator of apoptosis), p53, IKZF3 and HEBP2, whereas Bcl-2 also interacts with APAF1, BNIPL, MRPL41, TP53BP2, FKBP8, BAG1, RAF1, EGLN3 and G0S2.