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The dimers were found to aggregate to form clusters possessing the structure of a quasi-smectic liquid crystal, where the long-chained FA dimers arrange longitudinally and alternately to make an interdigitated structure in the clusters, with the tail of two dimers near the interacting head groups of the adjacent one.
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In contrast to many models in which Scc1 bridges a gap between the Smc heads, we find that the subunit is more likely to lie across two interacting heads, perpendicular to what would be expected from a bridge.
Assuming further that only those heads oriented towards one side, that is, one quarter, can interact with the actin filament, and that only one head of the head pair is favorably oriented to interact, we estimate the average number of interacting heads as 30 per myofilament.
Since cells are forced to interact head-to-head when cultured on 1D-substrates, this might account the observed improvement of the efficiency of CIL on 1D versus 2D-cultures.
The changes in those dipole moments that are affected by interactions with myosin heads do reflect the XB cycle (remembering that labeled actins that are too far from the interacting myosin head and unlabeled actins do not contribute to the change in signal).
PACAP mechanisms interact with head pain at a number of loci.
(A ) Mean tension force F within the myofilament when bending of actin is not allowed; dependence on ATP concentration for several different numbers of interacting myosin heads nm.
b Mobile phone interaction with head [mobile phone handset interacted with three layered head model].
"During his stint with the ADB, he interacted with heads of all major central banks in the region and as a result has built good relations," says Mr Schulz.
High resolution crystal structure showed an unusual arrangement, with three molecules of EhCaBP1 interacting in a head to tail manner to form a trimer [10].
In muscle, myosin dimers form (thick) filaments with interacting tails and head domains projecting outward from the filament to associate with complementary actin (thin) filaments in a muscle sarcomere [ 8].
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