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Our model accounts for the expression of four mutually interacting gap genes, hunchback (hb), Krüppel (Kr), giant (gt), and knirps (kni), and takes into account the expression of the genes bicoid (bcd), caudal (cad), and tailless (tll) as external inputs.
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This model indicated that GDIs sustain the activation of Rho GTPase by interacting with GAPs.
RhoGDIs positively regulate Rho GTPase signaling primarily by interacting with GAPs and may participate in the switching between transient and sustained signals of the Rho GTPases.
Other interactions include cholesterol, which was shown to interact with gap junction channels in different ratios during fiber cell differentiation in embryonic chicken lens [ 130].
G3BP1 colocalizes and physically interacts with GAP at the plasma membrane of serum-stimulated but not quiescent Chinese hamster lung fibroblasts.
The polymerase domain binds the 3′-end of the gap, interacting with the primer-terminal base pair and the upstream duplex DNA.
The effect of PFOA on GJIC was probably not a consequence of directly interacting with the gap junction proteins because the inhibition of MAPK and PC-PLC both prevented the GJIC effect.
In the case that one UE's required content is stored at its associated GAP, the UE will fetch the content directly from the GAP without interacting with the remote content server.
And so she closes the gap by interacting with her audience.
In the present study, we constructed a model of the Rho GTPase cycle, designated as the GDI-integrated model, in which GDIs inhibit the activities of GEFs and GAPs by interacting with them in addition to sequestering the Rho GTPases.
According to these observations, we constructed a model of the Rho GTPase cycle in which GDIs inhibit the activities of GEFs and GAPs by interacting with them as well as by sequestering Rho GTPases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com