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We identified chromosomal interacting regions with different levels of interacting frequency as well as E2-mediated differential chromosomal interactions, and further correlated them with eight histone modification marks, DNA methylation, regulatory elements regions, ERα and Pol-II binding activities.
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According to the DNA-interaction frequency, the interacting gene pairs were sorted in ascending order and then classified into four groups (corresponding to four quartiles).
We subsequently examined the top 10 highest chromosomal interacting regions above 30% interaction frequency at control condition (Table 2), as defined as top 10 hot regions, where 7 of them remain above 30% interaction frequency and the rest 3 drop to > =25% interaction frequency at E2-treated condition.
Consideration was given to the purpose (single-use vs. programmatic), level of simulation (individual vs. cohort), relationship between individuals (independent vs. interacting), and frequency of outcomes/health states (recursive vs. non-recursive).
Tests for interaction showed that none of the following covariates interacted with frequency of check-ups at the GP: working status (p = 0.24), gender (p = 0.40), age (p = 0.16), health status (p = 0.17), experience with heart disease (p = 0.50) (Table 3).
However, optimal amplitude level varied by individuals and also interacted with frequency.
The bias toward penultimate stress results in a "regularity" advantage for penultimate words in reading aloud [11], [12], that interacts with frequency such that it is much smaller for high-frequency words.
Steyn-Ross et al.[ 46] posit that the interacting low-frequency Hopf and Turing instabilities may form the substrate for the cognitive state, namely, the "default" background state for the non-cognitive brain.
3C contact maps record interactions between different sections of the chromosome in the form of a weighted adjacency matrix A where two fragments i and j interact with frequency A i j.
To understand the ERα binding information within these high frequency interacting regions, a publicly available [ 13] ChIP-seq data of ERα at the E2-treated and control condition in MCF7 cells was used.
The performer barely moves, there are no lyrics to relate to, there isn't a tune - and the only "beats" are the throbbing moments when two waves get close in frequency, interact, then glide their separate ways.
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