The CTD-interacting domain found in other eukaryotic Pcf11p proteins is present in two of the Arabidopsis orthologs [ 39], suggestive of a similar bridging function.
The TRAF family members, six to-date, are well-known to bind to the TIR domain of TRIF with their C-terminal [36], [37], [38], [39], while two members of the RIP family, RIP1 and RIP3, are found to interact with TRIF through the RHIM domain found in RIP1, RIP3 and TRIF [40], [41].
Responding to the activated insulin receptor, PI-3' kinase generates the second messenger phosphatidylinositol-3,4,5-P3 phosphatidylinositol-3,4,5-P3 phosphatidylinositol-3,4,5-P3omain found in several proteins involved in the PI-3' kinase signaling and recruits them to the plasma membrane.
This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.
BAT3 contains a so-called BAG-domain (Bcl-2-associated athanogene domain found in the BAG family of proteins) that interacts with Hsp70 [12].
This domain is similar to one (the so-called ECT domain) found in a family of Arabidopsis proteins that interact with calcineurin B-Like-Interacting Protein Kinases [ 42].
Since the intact full-length ATase contains the AT domain found in the ATC3 polypeptide, we also investigated whether ATN6 could interact with the full-length ATase.
The general concept is that the PY motif of the target protein has to interact specifically with the WW domains found in the Nedd4-like ligase in order to become ubiquitiated [ 26].
Collins et al. (2014) speculate that Corolla and C 3 G may interact via the predicted coiled-coil protein domains found in each protein.
Interestingly, the interacting genes are not the same interacting genes found in the colorectal cancer network.
NOD1, also called caspase recruitment domain (CARD -4 protein, appears to interaCARD -4 motifs found in the proteinglycappearsgram-negatove bacterinteract 12].
