The brain is organized as a distributed system, with different anatomically and functionally connected areas interacting in coordination to produce complex behaviors.
The three case studies described above highlight many organizational, institutional, and complexity concepts described previously, such as consideration of how organizations interact; ensuring adequate coordination; and adaptability to evolving environments.
For example, amino acid residues close to the C-terminal region of α-helix-1 and the nearby loop between β-strand-1 and α-helix-1 interact with Cu2+ coordination groups in the N-terminal region of the protein [ 73].
We thus conclude that the polymer is interacting with the anion coordination shell, which is accompanied by a very beneficial effect on the local lithium dynamics, as the polymer PDADMATFSI reduces the Li-TFSI interactions.
The resulting structure shows a partially hydrated magnesium ion located in the active site, near both the scissile phosphate and C75, interacting through outer-sphere coordination with two water molecules with a G25 U20 reverse wobble.
Molecular docking simulations suggested the novel inhibitors suppress APN activity by an alternative mechanism to Zn coordination: they interacted with residues comprising the S1 and S5′ subsites of APN.
In this review, we discuss how various classes of platinum II) complexes, which can interact with DNA by coordination, intercalation and other noncovalent modes of binding or by combination of these DNA binding modes, can alter the cellular response induced by conventional platinum drugs.
We have already seen that neighboring sterol molecules (corresponding to the 1 nm coordination shell) interact in such a way that a particular triangular symmetry appears in their relative spatial distribution.
Based on this model, it is hypothesized that the catalytic magnesium ion interacts through inner-sphere coordination with the 2′-OH group of U −1), lowering its p Ka and activating it for nucleophilic attack on the scissile phosphate.
The coordinating group is an exception here, their highest tie density shifts along with the issue at stake (flood protection or nature), so the coordination group interacts most strongly with flood protection group in the blue network, and with the nature group in the green network.
