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With so many services interacting at the same time, the chance of failure increases exponentially, and one failure can quickly lead to others.
Thirty clusters have 100% of their members with the same interaction, one has 75%, one 66.6%, and the rest (8) have 50% of their members interacting at the same point in the pathway.
When both transcription factors are interacting at the same promoter there is the possibility of transcription due to the binding of one transcription factor, transcription due to the binding of the other, and transcription due to the binding of both.
On the basis of a KM for tNAD+ 30-fold lower than that for UQ0, the concentration of tNAD+ in the reaction mixture should have prevented UQ0 from binding to reduced NDH-2 if both electron acceptors were interacting at the same site.
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For an alternative binding interaction to be deleterious, the proteins need to have a deleterious interaction (as defined by biological fitness) and to have the potential to interact at the same time, in the same cellular location, at the right concentration [ 42].
So when two particles interact at the same location, there is no way of knowing which is which.
We have performed molecular modeling studies on several σ1 specific ligands, including PD144418, spipethiane, haloperidol, pentazocine, and others to develop a pharmacophore for σ1 receptor ligand binding, under the assumption that all the compounds interact at the same receptor binding site.
As a massively multiplayer online computer game, Planet Michael will allow huge numbers of users to interact at the same time; it's free to download and play but users can convert their real dollars into play money in the game for virtual transactions.
Gund et al. have reported the molecular modeling of several σ1 receptor specific ligands: PD144418, spipethiane, haloperidol and pentazocine in a bid to develop a ph4 for σ1 receptor-ligand binding under the assumption that all the compounds interact at the same receptor site [13].
Several evolutionary forces may, however, interact at the same time.
However, unlike protein complexes, these proteins do not necessarily interact at the same time and location.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com