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They are thus thought to function by interacting at the cell surface with sequence-specific DNA-binding proteins (DNA receptors) and/or components of the type 4 pilus system responsible for DNA uptake.
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Furthermore, mucins are likely to be the first molecules that invading microorganisms interact with at the cell surface and thus can limit pathogen binding to other glycoproteins and limit infection (8).
We next investigated whether the TNAP interacting with PrPC at the cell surface of 1C115-HT and 1C11NE cells was functional.
Many of these proteases also modulate other cellular functions, either directly by interacting with receptors at the cell surface or indirectly by activation of latent molecules in the extracellular milieu.
Taurolidine mechanism of action is necessarily impacted by its easy hydrolysis [23], Figure 1, in aqueous solution; this results in the production of several metabolites and earlier findings suggested that the methylol-containing species that are produced during taurolidine hydrolysis could interact at the bacterial cell wall [24].
The hydrophobins interact at the fungal cell surface creating a hydrophobic surface layer and are important in many morphogenetic processes such as sporulation, fruiting body formation and infection structures [ 51].
Additional proteins seem to interact with sarcoglycans at the cell membrane.
Our results showed that AnxA2 interacts with EGFR at the cell surface of JIMT-1 cells transfected with control or tPA siRNA (Supplementary Figure S1B).
This injury occurs in the presence of serum which would contain HIP that may interact with heparanase at the cell surface.
Moreover, glycans may interact with galectins at the cell surface, which may lead to their enrichment in membrane lipid domains as previously described [ 40].
The ability of SDC4 to interact with molecules at the cell surface via its core protein as well as its GAG chains may uniquely regulate the formation of cell surface signaling complexes following engagement of this PG with its extracellular ligands [ 122, 123].
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