The pharmacophore represents three carboxylic groups interacting with the respective side chains of PSMA, one oxygen being part of the zinc complex in the active center, and as provided by HBED-CC, an aromatic structure element which is able to interact with the hydrophobic part of the enzyme composed of tyrosines [31, 32].
Our results also indicated that both of these X-family DNA polymerases can directly interact with the respective DNA glycosylases that could help direct the polymerases to the vicinity of alkylation-induced and oxidation-induced base damage, respectively.
The peptide sequences of AVP and OT differ only in 2 amino acids in positions 3 and 8, which enable these hormones to interact with the respective receptors [6].
Such a large number of identified candidate proteins enable the allocation of protein complexes interacting with the respective DNA target.
Both proteins lack an RNA-binding domain (RBD), which is suggestive of a cofactor that can directly interact with the respective RNA sequence.
He interacted with the researchers.
All λ cI -LTTR proteins interacted with their respective thioredoxin fusion, as indicated by the black boxes in Figure 2. Surprisingly, some heterotypic interactions were observed, particularly with the Trx-HdfR fusion against λ cI -YafC, λ cI -CynR and λ cI -YiaU, as indicated by the gray boxes.
It was simply moving to see how enthusiastically the Nigerian and South African participants interacted with their respective Ambassadors.
Most current biosensors consist of an enzyme or an antibody which interacts with the substrate or the respective antigen.
The crystal structures of the PLP synthase of T. maritima and B. subtilis demonstrate that the dodecameric complex of Pdx1 is decorated by the identical number of Pdx2 monomers, which in turn have no direct contact to one another and are therefore interacting only with the respective Pdx1 protein [15], [16].
