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This is problematic for Class II HLA binders since peptides partially interact with Class II HLAs.
They might also interact with class I HDACs to regulate histone acetylation (Mejat et al., 2005).
This has been observed for orthosteric ligands that interact with class A GPCRs in recent crystal structures [ 30].
Thus, CitBLH1 might interact with class I KNOX proteins participating in certain abscission events in the LAZ of citrus leaves.
For example, the class I bHLH protein ITF-2B encoded by the gene ITF2 is known to interact with class II and class V bHLH proteins [ 22].
It can interact with Class II HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) via the transcriptional co-repressor NCoR/SMRT ([ 13, 14] and reviewed in [ 15]).
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All of the Rab11 family members can interact with classes of Rab11-family interacting proteins (Rab11-FIPs) as well as the actin-based motors Myosin Va and Myosin Vb (Hales et al, 2001; Lapierre et al, 2001; Roland et al, 2009).
But the IPPR recommends that we should be cautious of celebrating the increasing numbers of women at the top as a marker of equality, and instead develop "a more nuanced understanding of how gender interacts with class disadvantage" to hold some women back, while others go forward.
SNX9 and SNX18 have both been reported to preferentially bind to PI 4,5 P2 [46], potentially indirectly facilitating the conversion into PI 3,4,5 P3 by interacting with class I PI(3)K to elevate macropinosome formation.
Beclin 1 promotes autophagosome formation by interacting with class III PI3-K, p150 myristoylated kinase, and other proteins.
Barley JuBEL1 also interacts with class I KNOX proteins BKN1 and BKN3, but not with class II KNOX protein BKN7 [ 31].
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