Subcritical segments placed near one another were observed to interact to generate electromigration damage and failure.
Therefore, our findings may reflect the complex relationship between iron and lead metabolism where the metals interact to further increase damage and, consequently, cognitive decline.
It has been well established that many levels of protection exist and that they interact to inhibit the DNA damage machinery at natural chromosome ends.
This comprehensive review focuses on the reported abilities of metal nanoparticles, metal-oxide nanoparticles, quantum dots, fullerenes, and fibrous nanomaterials, to damage or interact with DNA, and their ecogenotoxicity is also considered.
Some pesticides and/or its environmental transformation products have the capacity to interact and damage the structure of the DNA, a process that often has a toxic outcome for human health.
Chlorhexidine, like chlorpromazine is a cationic compound known to interact with and damage cellular membranes [ 41], hence it is logical that both compounds induce the efflux pump and that the efflux mutant demonstrated sensitivity to this disinfectant.
These findings are consistent with several studies that found better survival among cancer patients with low activity GSTP1 alleles, implying that genotypes associated with lower GSTP1 activity allow reactive intermediates to interact with and damage both tumor and normal cells.
Two independent groups recently demonstrated the ability of Chd1l to respond to DNA damage by interacting with PAR (Ahel et al., 2009; Gottschalk et al., 2009).
Finally, in an actual radiological emergency, multiple environmental factors may interact synergistically to effect DNA damage.
We show that taperin is a predominantly nucleoplasmic protein, which can interact with DNA damage response proteins and accumulate to sites of DNA damage upon UV-irradiation.
