As positives, protein-protein interactions experimentally shown to interact are considered, while a negative set of protein pairs was built by making random combinations between all proteins, which is an approximation of true negative protein pairs (see Methods for details).
It has been shown that pairs of genes that genetically interact are more likely to encode interacting proteins than random pairs of genes (Kelley and Ideker, 2005; Tong et al., 2004; Wong et al., 2004).
Protein-protein interactions (PPIs), which we define as proteins that physically interact, are crucial in most complex biological processes.
Baranzini et al. [ 10] suggest that the network-based approach not only reduces the number of relevant interactions found but also increases the likelihood that proteins that interact are part of the same biological pathway [ 10].
The body's controls on how those two systems interact are lost the moment both are cultured in a plastic dish.
But although his tales of how genes and environment mutually interact are largely accurate, he still has problems in recognising just how complex are the biological and behavioural issues.
Indeed, the ways in which AIDS and India's traditions interact are a striking feature of these essays about the disease in India, commissioned by the Gates Foundation.
Biographies that capture not only the people involved but also how they interact are a welcome antidote to the impression that the best science is done by the genius alone in his garret.
These components interact (are connected) by continuously exchanging data as streams.
As it happens, opportunities to work in an environment where mathematicians and biologists interact are mushrooming.
