The attenuation of the inverse associations we observed between total fibre, cereal fibre and vegetable fibre and diabetes after adjustment for BMI in the EPIC-InterAct analysis suggests that the beneficial effect of fibre may be partly mediated by a lower BMI, and this is consistent with other studies [ 5, 33].
With the pair end ditag concept, we further explored the ability of PET to connect two ends of DNA and delineate their relationships to characterize interacting chromatins (chromatin interaction analysis by pair-end-ditagging; ChIA-PET) [ 50].
To investigate RQ2.2, we again conducted an interaction analysis as students interacted with MIC-O-MAP, similar to the study in cycle 1.
As all risk factors have a high potential to interact, factor analysis was used to exclude multicollinear variables.
Interacting partner prediction analysis indicates that it interacts with a wide range of proteins and enzymes like phosphotyrosyl phosphatase activator, Hsp70/Hsp90 organizing protein (HOP), tRNA m5C-methyltransferase, mRNA-decapping enzyme 2 (DCP2), and actin-like protein.
"If you want to understand living things, you really have to let all these levels of analysis interact," Dr. Ryan said.
To determine whether I3C and bortezomib interact synergistically, isobologram analysis was performed.
The graphical output and the possibility to interact with the analysis at various stages, give the users a high level of control over the identification process.
A broad range of topics has already been explored empirically in this way and the respective articles cover a wide spectrum in relation to their aims and the ways in which empirical research and normative analysis interact.
To analyze which of the proteins encoded by the genes with the highest contribution to the similarity between GCPs truly interact, a network analysis was done with the genes that contributed at least 0.1% to the CS.
Other cases include the fusion of HisH/F, two histidine biosynthesis enzymes, predicted to interact through structural analysis [ 26] and the plant PHYLLO locus for vitamin K1 biosynthesis, present in photosynthetic cyanobacteria as a homologous gene cluster of the men (F/D/C/H) genes [ 27].
