For any Web document set, the set of Web resource with inter-relationship information can be obtained and expressed as a preliminary RDF diagram using a crawler-like algorithm, as shown in the following Figure 2: Figure 2 Algorithm to generate relationships among object resources.
However, the limitation of previous work was that we integrated with multi-layers of genomic data without considering of inter-relationship information between genomic features.
The main problem of this study is to develop an adequate measure to calculate the similarity matrix containing inter-relationship information between miRNA and gene expression.
Thus, a new measure for calculating the similarity matrix containing inter-relationship information from different levels of genomic data has been developed in this study).
The results indicate that the use of inter-relationship information of miRNA expression and genomic features such as DNA methylation and copy number variation has the potential to elucidate tumorigenesis processes and improve therapeutic strategies for cancers other than GBM.
However, the limitation of previous work was that we integrated with multi-layers of genomic data for cancer clinical outcome prediction without considering of inter-relationship information between genomic features [ 14].
However, it is difficult to calculate the similarity matrix containing inter-relationship information between miRNA and target genes because the length of vector from two matrices is different, for example 534 miRNAs and 12,043 genes in miRNA and gene expression, respectively).
Despite the difficulty of developing an adequate measure to calculate the similarity matrix containing inter-relationship information between miRNA and gene expression, we implemented 4 measures, GR_1, GR_2, GR_3, and GR_4, and compared with the proposed method, GR_5, in order to assess the benefit of the proposed one.
A weight matrix containing inter-relationship information between miRNA and target genes is obtained by (4) f i j = ∑ l = 1 N m i ∑ m = 1 N G m i R N A (i, l ) ∙ g e n e (j, m ) where m-th gene is targeted by l-th miRNA.
The truth lies in a combination of the two and the inter relationship of both.
Broadly, it suggests a unified approach to project management that involves defining a set of widely-applicable common views of the project information, explicitly defining the inter-relationships between the information in these different views, and modifying project management tools and procedures to work with these integrated views.
