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Intent to diagnose (subspecialists).
Today, ANA test ordering practice follows one of the following patterns: 1. Intent to diagnose (subspecialists) .
Therefore, in attempting to establish a more effective ovarian cancer surveillance programme, clinicians may consider altering the frequency of imaging and CA-125 evaluation based upon prognostic risk factors, such as disease stage and cancer origin, with intent to diagnose progressive disease earlier and potentially improve upon patient outcomes (Fehm et al, 2005).
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Simulation studies showed that the intent-to-diagnose approach under-estimate sensitivity and specificity.
In all individuals, irrespective of image quality, every arterial segment was scored in an intent-to-diagnose fashion.
The intent-to-diagnose approach largely under-estimates both sensitivity and specificity (12.6% and 11.9% bias, respectively).
The intent-to-diagnose approach provides lower estimates for sensitivity, specificity and AUC as it is the most conservative approach.
The paper conducted a meta-analysis of coronary CT angiography studies and presented an intent-to-diagnose approach together with three commonly applied alternative approaches.
Under MAR assumption, the intent-to-diagnose approach under-estimate both sensitivity and specificity, while the extended TGLMM gives nearly unbiased estimates of sensitivity, specificity and prevalence.
The performance of the intent-to-diagnose approach, the alternative approaches and the extended TGLMM approach is examined by extensive simulation studies.
For each simulated meta-analysis data set, the extended TGLMM, Model 1-3 and the intent-to-diagnose approach are fitted.
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