The target-mining strategy using this '-omics' data was based on the premise that if the protein was intensively targeted by AD drugs, but did not tend to be targeted by the control drugs it should be prioritized and be measured for its potential therapeutic benefit to AD.
Gene ontology analysis of S.erythraea genes most intensively targeted for destruction at the metabolic switch returned a large enrichment for transcripts associated with the translational process, including ribosomal genesis (4.6-fold, p = 2.12x10-5), ribosomal proteins (1.4-fold, p = 6.3x10-7) and other associated translational factors.
They had to have been intensively targeting widely spaced but relatively abundant resources on the landscape.
Moreover, as suggested for many commercial and recreational fishes (Beard and Essington 2000; Law 2000; Kuparinen and Merilä 2007; Sharpe and Hendry 2009), our model predicts that intensively targeting large fish can affect strong plastic and evolutionary changes in growth and life-history traits.
If control campaign frequency was reduced to twice yearly, the total control effort (number of campaigns) had to be increased substantially, because "temporal refuges" allowed the disease to spread in initially less-intensively targeted host populations, with enhanced numbers of susceptibles between each reproduction period.
Due to the important role that aspartic proteases play in many patho-physiological processes, they have intensively been targeted by modern drug development.
First, fisheries-induced disruptive selection is readily caused by commonly used fishing policies, and occurs even for policies that are not specific for fish size or maturity, provided that the harvest is sufficiently adaptive and large individuals are targeted intensively.
Reef sharks, including tiger (Galeocerdo cuvier), lemon (Negaprion brevirostris), sandtiger (Carcharias taurus) and silky (Carcharhinus falciformis) began to be targeted intensively in the early 20th century for their liver, skins, meat and fins [19] and commercial catches increased after 1950 [2], [20], [21].
The leisure time context of PA was targeted more intensively by almost all the organizations in the present study and may be related to the significant differences in PA levels during leisure time activities (small but considerable effect sizes for a whole-community project) of citizens.
Current guidelines recommend treating patients with early rheumatoid arthritis (eRA) immediately, intensively and to target [ 1- 3].
Over the past several years, a few research groups including our laboratory have intensively aimed at targeting SOD1 mRNA by RNA interference (RNAi).
