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In monocytes, T. whipplei was rapidly eliminated in phagolysosomes characterized by the presence of Lamp-1 and cathepsin D. In macrophages, a large number of bacteria were eliminated in an early phase, but the remaining bacteria survived and intensively replicated in a late phase.
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Interestingly, Foxp3+CD25+CD4+ regulatory T cells are highly enriched following infection, both in the periphery and in the brain, where the virus intensively replicates.
Therefore, we analyzed the frequency of regulatory T cells (Foxp3+ CD25hinh CD4+) in the brain of MV-infected mice, where the virus intensively replicates [24].
At time of death the observation that at least 10% of CD8+ T cells were infected suggest that these cells replicate intensively and/or lead to the deletion of non infected cells.
Indeed, some of them, such as Rickettsia rickettsii or Chlamydia spp., prevent cell death to replicate intensively within host cells, while others, such as Yersinia pestis or Bacillus anthracis, induce apoptosis to favor bacterial spreading.
He replicated it.
It cannot be replicated.
This should be replicated nationwide.
Could the moment be replicated?
That can't be replicated".
How can success be replicated?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com